Limited cross strain CMV protection by a bivalent (gB/pp65) vaccine is based on an impaired gB antibody response and evasion of pp65 cell mediated immunity
Congenital CMV (cCMV) is a leading cause of hearing loss and cognitive impairment in newborns and a vaccine is a high priority. The guinea pig with species-specific guinea pig cytomegalovirus (GPCMV) is the only small animal model for cCMV. Prior GPCMV vaccine studies have focused on prototype strain 22122 and not evaluated cross-strain protection, an important vaccine benchmark. The essential…
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