Glioblastoma Hijacks Astrocyte Ribosomes to Feul Malignancy through Translatome Reprogramming
Cancer cells demand elevated protein synthesis, yet whether they directly requisition ribosomes from microenvironmental host cells remains unknown. Here, utilizing in vivo and in vitro ribosome tracing, we show that glioblastoma (GBM) cells hijack ribosomes from surrounding astrocytes via tunneling nanotube-like structures. This transfer supports GBM malignancy in both murine and patient derived…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
