ASN: Low protein intake linked to kidney failure risk in Asian patients with CKD
Among patients with non-dialysis-dependent chronic kidney disease (CKD), low protein intake is associated with an increased risk for kidney failure requiring replacement therapy (KFRT) and all-cause mortality, according to a study published online Oct. 22 in JAMA Network Open to coincide with Kidney Week, the annual meeting of the American Society of Nephrology, held from Oct. 21 to 25 in Denver.
A study published in JAMA Network Open on October 22 suggests that low protein intake may increase the risk of kidney failure and mortality in non-dialysis-dependent chronic kidney disease (CKD) patients, particularly in Asian populations. Researchers from Chonnam National University Medical School in South Korea analyzed data from 1,861 participants with CKD at stages 1 to predialysis 5.
The study found that those with a daily protein intake (DPI) below 0.6 grams per kilogram of body weight had a higher risk of kidney failure requiring replacement therapy (1.42 subdistribution hazard ratio) and all-cause mortality (2.17 subdistribution hazard ratio) compared to those with a DPI of 1.2 grams per kilogram of body weight.
The relationship between protein intake and kidney failure risk appeared nonlinear, indicating that excessively low protein intake may be linked to increased risks of kidney failure and mortality. This finding challenges the universal application of strict low-protein diets across all ethnic groups, especially considering the vulnerability of Asian populations with lower body mass index and muscle reserves.
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