An energy-dependent integrate-and-fire model explains coordinated synaptic and intrinsic adaptation under metabolic stress
Neuronal computation is constrained by the energetic cost of maintaining synaptic transmission, ionic gradients and action-potential generation. Prior work has shown that food restriction in mice shifts visual cortical neurons toward a different operating regime characterized by reduced excitatory synaptic drive, increased membrane resistance and a more depolarized resting membrane potential.…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
