Adaptive responses to antifungal selection depend on dose and drug combination in experimentally evolved yeast
Natural populations rarely face a single stressor at a single intensity, yet most laboratory evolution experiments impose exactly that. Theory predicts that stronger or compounded selection pressures should change the magnitude of adaptive change as well as the specific loci involved, but this prediction is rarely tested directly. Here, we use an evolve-and-resequence approach to compare genomic…
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