Viral subversion of the host ubiquitin proteasome system is broadly sensed by the NLRP1 inflammasome
NLRP1 is an inflammasome-forming sensor that can detect diverse pathogen virulence factor enzymatic activities, including that of bacterial and viral proteases, to promote effector-triggered immunity. Additionally, the mouse NLRP1B inflammasome can sense the E3 ligase activity of the Shigella flexneri secreted effector IpaH7.8. Here, we investigated whether viral subversion of the host ubiquitin…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
