Transient Partial Inhibition of DNA Polymerase α Promotes Chromatin Plasticity and Enhances Human Cell Reprogramming
Somatic cell reprogramming requires extensive remodeling of epigenomic and transcriptional state, yet the mechanisms that enhance chromatin plasticity during cell-fate conversion remain incompletely understood. Beyond its essential role in genome duplication, DNA replication provides a dynamic window for chromatin remodeling and may therefore influence cellular plasticity during reprogramming.…
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