Stromal COL12A1 defines a pro-invasive extracellular matrix niche in appendiceal mucinous neoplasms and pseudomyxoma peritonei
Pseudomyxoma peritonei (PMP) is an uncommon peritoneal malignancy, most often arising from appendiceal mucinous neoplasms (AMNs), in which tumour progression is accompanied by extensive mucus accumulation. Although PMP is clinically dominated by peritoneal dissemination, the stromal matrix cues that support invasion and metastatic niche formation remain poorly defined. Here, we profile…
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