Single-cell profiling quantifies the dose gap between population-average and complete pY-STAT1/3 suppression by JAK inhibitors
Inhibitor potency is commonly assessed from population-average responses, but how much single-cell signaling remains under strong average suppression is less clear. We measured nuclear STAT1 and STAT3 tyrosine phosphorylation in two human monocytic cell lines stimulated with IFN-{gamma}; and IL-10 and treated with six JAK-pathway inhibitors. Across 24 profiles, we compared arithmetic-mean…
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