Sensitive untargeted metabolomics via 3-nitrophenylhydrazine derivatization maps gut microbiota-related metabolites across multiple mouse biological compartments
The gut microbiome communicates with distal organs via small molecules, yet systematic tracking of gut microbiota-related metabolites across host compartments remains limited. Although 3-nitrophenylhydrazine (3-NPH) derivatization improves sensitivity for carboxyl-, carbonyl- and phosphate-containing metabolites, the resulting derivatives cannot be identified against conventional spectral…
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