Neutrophil Extracellular Trap Deposition Establishes an Immunosuppressive Environment in Non-metastatic Lymph Nodes and Facilitates Heterologous Metastatic Outgrowth
Metastasis accounts for most cancer-related mortality, and regional lymph nodes (LNs) are among the earliest sites of dissemination for many solid tumours. Yet tumour-draining lymph nodes (TDLNs) are also sites of adaptive immune activation, raising the question of how these immune organs become permissive to metastatic growth. We investigated whether neutrophil extracellular traps (NETs), which…
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