Neuronal Hyperactivity Induces Tau Phosphorylation Selectively in Excitatory Pyramidal Neurons Which Contributes to GluA2 Regulation
While tau plays a role in regulating neuronal network excitability, a process thought to be dysregulated in Alzheimers disease (AD), the molecular mechanisms linking tau and hyperexcitability remain unclear. To investigate interactions between endogenous tau and neuronal activity, we increased neuronal activity using bicuculline or suppressed activity using tetrodotoxin for 24 hours in rat…
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