Multi-resolution humanness scoring of antibodies via a region-isolated language model
Antibodies recognized as foreign can elicit anti-drug antibodies that compromise efficacy and safety, making humanness scoring---estimating how human-like a sequence appears---an early, repeated step in antibody development. Widely used scores reduce a variable domain to one framework-dominated number, leaving the complementarity-determining regions (CDRs)---grafted during humanization,…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
