Human Saliva Induces Acetoin-Dependent Metabolic Adaptation that Promotes Stress Tolerance in Streptococcus mutans
Oral microbes are continually exposed to host-derived saliva, yet its effects on bacterial metabolism and stress adaptation remain incompletely defined. We investigated how saliva supplementation alters the physiology of the caries-associated bacterium Streptococcus mutans using transcriptomics (RNA-Seq), targeted metabolite measurements, specific gene deletions, and transposon sequencing…
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