Heat-dependent engagement of a buried mitophagy motif in prohibitin 2
Mitophagy receptors are generally switched on by upstream enzymes rather than by the receptor itself. Whether a receptor can instead respond directly to a physical stimulus has not been established. Here we show that a second LC3-interacting region (LIR) in prohibitin 2 (PHB2) is regulated by temperature. It lies in a marginally stable helix that holds its two anchor residues about 5 angstrom…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
