Glial cells gate small RNA transport from germline to brain during transgenerational epigenetic inheritance of behavior
How circulating RNAs reach their target tissue is not well understood. In C. elegans, small RNA signals that convey exposure to pathogenic Pseudomonas travel from the intestine to germline to neurons, allowing both learned pathogen avoidance and the transgenerational inheritance of this information for four generations, but how this Cer1 retrotransposon-bound RNA signal reaches the nervous system…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
