Engineering a gut bacterium depleted in industrialized microbiomes to survive malabsorption
Industrialization is associated with the depletion of key gut microbial taxa and increased exposure to environmental perturbations such as malabsorption, which elevates intestinal osmolality. Here, we focus on Muribaculaceae, a family prevalent in rural Indigenous populations but depleted from industrialized microbiotas and highly sensitive to osmotic stress. We identified the opuA betaine import…
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