Detergent lysis controls are critical for single extracellular vesicle phenotyping in SP-IRIS platforms
Bulk analytical methods are extensively used to identify molecular cargo in extracellular vesicles (EVs), but they cannot distinguish nanovesicles from co-isolated non-vesicular particles or resolve discrete EV subpopulations. Single-particle interferometric reflectance imaging coupled with immunofluorescence (SP-IRIS/IF) has emerged as a platform to simultaneously resolve particle size, count,…
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