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Charting vulnerability of brainstem functional pathways in aging and prodromal synucleinopathy

The brainstem is vulnerable to aging and prodromal synucleinopathy, yet whether these processes disrupt shared or distinct functional pathways linking the brainstem to the cortex remains unknown. Using high-resolution 7-Tesla fMRI, we mapped connectivity between 58 brainstem nuclei and cortical regions in young adults, older adults and individuals with isolated REM sleep behavior disorder (iRBD),…

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