CD44-CD206 axis drives dendritic cell loss and immunosuppression in immaturely glycosylated bladder tumours
Antigen-presenting-cell dysfunction drives immune exclusion, but how tumour glycans disable these cells remains incompletely defined. Immature O-glycosylation, marked by Tn and sialyl-Tn antigens, drives myeloid dysfunction in bladder cancer. Transcriptomics and human tumour profiling linked this state to reduced representation of antigen-presenting myeloid cells and attenuated lymphoid-effector…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
