A cell-free system for mitotically-stimulated TMEJ
Double-stranded DNA breaks (DSBs) are cytotoxic and must be repaired to avoid cell death or mutagenesis. DSBs that form in the S or G2 phases of the cell cycle undergo end resection, creating substrates for homologous recombination (HR) and alternative end joining pathways. Theta-mediated end joining (TMEJ) is a DNA polymerase {theta} (Pol {theta}) dependent repair pathway that joins resected DSB…
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