3D-genome impacts of TAD-boundary-disrupting ultra-rare structural variants identified in schizophrenia
Schizophrenia is a complex and multifactorial brain disorder that impacts ~1% of the U.S. population. The genetic architecture of schizophrenia includes 10 large rare structural variants (SVs) ~10 exonic variants, and over 250 common variants. Previously we combined whole genome sequencing (WGS) with brain-specific epigenomic data and found an excess of ultrarare SVs in schizophrenia localizing…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
