The human-specific lncRNA HD-LINC drives lipid droplet-associated neurodegeneration in Huntington's disease
Huntington's disease (HD) is characterized by degeneration of striatal medium spiny neurons (MSNs), yet the human-specific regulatory mechanisms that contribute to neuronal vulnerability remain poorly understood. Here, we identify HD-LINC (LINC01139), a human-specific long intergenic noncoding RNA selectively induced in symptomatic HD patient-derived MSNs (HD-MSNs) and human HD caudate.…
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