NMR-measured Per-residue Electrostatic Potentials Reveal the Importance of Arginine-Lysine Balance on the Conformational Ensemble of Disordered Histone H3 Tails in Nucleosome Core Particles
Biophysical studies of chromatin have provided key insights into how the genome is regulated. Many atomic resolution structures of the fundamental building block of chromatin, the nucleosome core particle (NCP), as well as larger NCP arrays, both in isolation and in complex with effectors, or with post-translational modifications, have been elucidated. These provide in-depth pictures of key…
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