MPFIL: Multi-Level Protein Feature Integration for Predicting Mutation-Induced Protein-Protein Binding Affinity Changes
Predicting mutation-induced changes in protein protein binding affinity ({triangleup}{triangleup}G) is challenging because mutations can affect both local residue environments and the structural organization of protein complexes. Existing approaches often rely on handcrafted physicochemical, energetic, or evolutionary features, which introduce additional computational costs and require…
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