IL-27 Reduces Cell-Surface LDLR in Human Macrophages and Restricts VSV-G-Pseudotyped HIV infection
Low-density lipoprotein receptor (LDLR) is a major cellular receptor for vesicular stomatitis virus glycoprotein (VSV-G), which is widely used to pseudo-type viral vectors. We previously showed that IL-27 suppresses infection by VSV-G-pseudotyped HIV encoding luciferase (VSV-G-HIVLuc) in macrophages; although IL-27 induced multiple anti-virus genes in cell, the underlying mechanism of VSVG-HIVLuc…
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