Human prion proteins and mutants through the lens of systems biology
Autocatalytic conformational changes of cellular prion proteins (PrPC) to the {beta}-sheet-enriched scrapie isoform (PrPSC) drive prion diseases, yet the precise molecular mechanisms remain unclear. To address this, we employ a multi-pronged framework integrating network-theoretic analyses, molecular dynamics (MD) simulations, and experimental validation to characterize critical residues…
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