FXR2 Promotes Autophagic Clearance of Sindbis Virus Capsid and Protects Against Viral Encephalitis
Autophagy protects neurons from viral infection by removing toxic viral components, but the host factors that recognize viral proteins and direct their clearance remain incompletely defined. Here, we identify fragile X mental retardation syndrome-related protein 2 (FXR2) as a mediator of protective autophagy during Sindbis virus (SINV) infection. Quantitative proteomic analysis of host proteins…
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