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Focal neuronal loss and cell replacement in a connectome model of fly steering

Focal neuronal loss after stroke, traumatic brain injury or spinal cord injury can disrupt circuits and result in persistent motor deficits. Which cells and connections must be restored to recover a specific behavior is difficult to establish experimentally. Here we use a connectome-constrained spiking model of the fruit-fly nervous system and decode motor-neuron output to simulate visually…

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