Additive and dominance gene effects described by a logistic function in concentration-limited metabolic pathways at steady state out of equilibrium
Abstract Additive (a) and dominance (d) gene effects are key to phenotype manifestation. We investigated the relationship between these effects and gene-encoded enzyme rates in an n-step linear metabolic pathway with mass limitation at stationary state out of equilibrium, where internal flux depended on internal enzyme concentrations (Ei, i=1 to n) and external flux on input/output…
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