A splenic reservoir of pro-angiogenic neutrophils supports blood flow recovery after peripheral tissue ischemia
Background: Neutrophils accumulate at sites of ischemic injury, where a distinct subset characterized by CD49d+CXCR4hiVEGFR1hi expression promotes angiogenesis and contributes to blood flow recovery. This study investigated the function, origin, and recruitment mechanisms of these pro-angiogenic neutrophils (PANs) in a murine model of hindlimb ischemia and explored whether a corresponding…
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