A pump-leak model of epithelia reveals the roles of paracellular pathways in water transport & the importance of boundary conditions
We develop a pump-leak model of epithelial transport, where the flux of water through the epithelium is modeled as a compartment, or sink, whose volume grows linearly with time. A method is described for calculating the voltage in the sink compartment, as well as analytical solutions to the system of equations. We show how growing boundary conditions can be used to model a scenario where water…
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