Understanding the role of IQ motif-containing GTPase-activating protein 1 as a potential disruptor of the essential adhesion module at cell-cell junctions
A key mechanism of stabilization of Cadherin-based cell-cell adhesions is through a mechanically modulated interaction to cortical actin filaments. This interaction is facilitated by a cytoplasmic adhesion module comprising of a complex of {beta}-catenin/-catenin. Recent evidence shows that under specific conditions the {beta}-catenin/-catenin complex gets disrupted because of mechanical…
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