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Spontaneous replication fork collapse regulates telomere length homeostasis in wild-type yeast

Proceedings of the National Academy of Sciences, Volume 123, Issue 44, November 2026. SignificanceIn most eukaryotes, the termini of linear chromosomes are composed of arrays of short repeats that are replenished by the enzyme telomerase. If telomerase is unable to act, gradual loss of these terminal repeats results in an eventual block to ...

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