SPARK: Bayesian structure learning of enhancer-based gene regulatory networks from single-cell multiomics data and prior knowledge
Enhancer-based gene regulatory networks (eGRNs) linking enhancers with recruited transcription factors (TFs) and downstream target genes can help decipher complex regulatory mechanisms, such as the function of GWAS variants at enhancers. Molecular assays that profile gene expression and chromatin state jointly from the same cells (such as 10x Multiome) are a rich source of input data for eGRN…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
