Sequential vaccination matures VRC01-class HIV-1 neutralizing antibodies in humans
Inducing a broadly neutralizing antibody (bnAb) response is a key goal of HIV-1 vaccine development. Despite significant progress, it is unknown whether vaccine-primed B cells can be reactivated and matured to secrete bona fide bnAbs. In the IAVI C107/C110 single-arm, open-label human trial, VRC01-class memory B cells previously primed by the GT1.1 germline-targeting envelope glycoprotein (Env)…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
