Intercalator effects on DNA loop extrusion by SMC proteins
Intercalating dyes are widely used to visualize DNA in single-molecule experiments, but their effects on DNA-processing proteins remain incompletely characterized. Here, we study the effects of intercalators on DNA loop extrusion by SMC complexes. Intercalating dyes become fluorescent upon DNA binding, enabling direct visualization of extruded DNA loops. As dye intercalation alters the…
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