Buffalo Bills open as slight favorites over Baltimore Ravens in Week 8

Orchard Park, New York - September 7, 2025 - The Buffalo Bills are set to open their Week 8 season as slight favorites against the Baltimore Ravens at their new Highmark Stadium. Following a successful two-game road trip, the Bills are now 5-1, sharing first place in the AFC with Baltimore, who sit at the bottom of the AFC North with a 4-3 record.

The oddsmakers at FanDuel Sportsbook have the Bills at a 3.5-point advantage (-3.5) over the Ravens. Baltimore's defense showed vulnerability against the Cincinnati Bengals, allowing 35 points. The over/under for the game is set at 53.5 points. Key injuries for the Bills include wide receiver DJ Moore (AC joint sprain) and defensive tackle Ed Oliver (hip), while the Ravens must watch quarterback Lamar Jackson's health, as he has missed the last three games with a high ankle sprain.

The 15th matchup between these teams has each side winning 7 games, with the Bills holding a 4-3 edge over the Ravens since 2018, including two playoff victories. Their last meeting in Week 1 of the 2025 NFL season saw a thrilling comeback win for Buffalo, guided by Josh Allen's leadership.