Targeting the Kidneys Osmotic Gradient with AVPR2 Antagonism Limits Inflammation and Fibrosis after Injury
Background: The renal medulla is characterized by a steep osmotic gradient that is essential for urinary concentration but may also influence cellular stress and injury responses. While vasopressin-dependent medullary hyperosmolarity is well established in water homeostasis, its role in shaping kidney injury and repair remains poorly understood. Methods: We pharmacologically reduced vasopressin…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
