Cyclin D1 is a central regulator of cell-cycle progression and a compelling therapeutic target in cancer, yet its non-enzymatic function, limited ligandability, and rapid turnover have hindered direct pharmacological intervention. Here we show that these limitations can be overcome by targeting a transient conformational state populated during protein folding. Computational reconstruction of the…
In 1987, biologists captured the last free-flying condor to transfer it to captivity, and the largest flying North American bird species was officially declared extinct in the wild.
