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Integrated Transcriptomic and Structural Prioritization of Sulforaphane Targets in Neurodegeneration: A Multi-Dataset In Silico Study

Sulforaphane (SFN), a natural isothiocyanate from cruciferous vegetables, exerts neuroprotective effects through mechanisms extending beyond canonical Nrf2/ARE activation. Here, we developed a multi-dataset computational framework integrating transcriptomic analysis, multi-criteria target prioritization, and structural docking evaluation. R- and S-SFN were docked against 693 prioritized targets…

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