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Hsp10 Targets the C-Terminus of α-Synuclein to Inhibit Secondary Nucleation and Remodel Labile Fibrils

Aggregation of a-synuclein is a central pathological feature of Parkinsons disease and related synucleinopathies. The co-chaperonin Hsp10, a component of the Hsp60/Hsp10 chaperonin system, has recently been proposed to possess independent chaperone activity and has been found to co-localize with a-synuclein aggregates in diseased brains, suggesting a role in regulating a-synuclein assembly. Here,…

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