Effector-primed TCF1+ CD8+ T cells elicited by a networked epitope vaccine stratify protection against SHIV acquisition
Effective T cell vaccines for human immunodeficiency virus (HIV) will require induction of durable antiviral CD8+ T cell responses, but the cellular states associated with protection from viral acquisition remain poorly defined. Here, we developed a networked simian immunodeficiency virus (SIV) epitope vaccine targeting structurally constrained viral regions and evaluated a heterologous…
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