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Cross-Tissue Concordance of Blood-Trained Protein EpiScores in Donor-Matched GTEx Tissues

Background: Protein EpiScores are DNA methylation (DNAm)-derived predictors of circulating protein levels that may provide accessible biomarkers of disease-related molecular variation. However, because these models were developed in blood, it remains unclear whether they preserve interindividual variation when applied to other tissues. We evaluated the cross-tissue concordance of blood-trained…

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