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Centered cross-context perturbation transfer on the public 2025 Virtual Cell Challenge benchmark

Predicting transcriptional responses across cellular contexts requires transferring both expression direction and differential-expression priority. We developed a compact numerical method that combines public perturbation summaries with a differential-expression kernel fitted to H1 CRISPRi training targets. The method centers an independent KOLF2.1J source on known training targets, transfers its…

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