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A synchronization modulation electric field reduces early ischemic kidney injury in pigs and suppresses a stress and inflammatory program without detectable leukocyte accumulation

Background. Acute kidney injury has no approved drug treatment. A synchronization modulation electric field (SMEF) keeps Na+/K+-ATPase working when ATP is scarce, and protects the rodent kidney from ischemia-reperfusion injury and human kidneys during cold storage. It has not been tested in a large animal in vivo, and what it changes in the tissue is unknown. Methods. Twelve female Yorkshire pigs…

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