Single-nucleus transcriptomics and phosphoproteomics identify misregulated sperm components in mice carrying a selfish supergene
The t-haplotype is a selfish variant of the mouse chromosome 17. It reaches 90-100% transmission rates in heterozygous (+/t) males through a poison-antidote system that disables sperm carrying the homologous (+) haplotype. While several poisons and one antidote have been identified, how these mediate drive, and what additional molecular players are involved, is not fully understood. Here, we…
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