Directional cell migration requires leading-edge protrusions to integrate actin polymerization, actomyosin contractility, and cell-matrix adhesion, but how polarity pathways spatially coordinate these processes remains incompletely understood. Wnt/planar cell polarity (Wnt/PCP) signaling promotes protrusive activity and migration in breast cancer cells. Here we identify the actin-associated…
Consumer sentiment in the U.K. tumbled at the fastest pace since the Covid-19 pandemic this month as mounting cost-of-living pressures reversed the bounce in optimism seen over the summer.
