Mitochondrial electron transfer depends on quantum-mechanical coupling between redox cofactors, but its evolutionary constraints in cancer remain unclear. We combined the human complex III cryo-EM structure, Pathways calculations and Marcus theory to predict how missense substitutions in mitochondrial cytochrome b (MT-CYB), which coordinates the Q-cycle haem centres, affect electron-transfer…
Consumer sentiment in the U.K. tumbled at the fastest pace since the Covid-19 pandemic this month as mounting cost-of-living pressures reversed the bounce in optimism seen over the summer.
