Prediction of Systemic Lupus Erythematosus from Genotype and1 Gene-Expression Data: Batch Correction and Leakage Free2 Evaluation
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with a strong genetic component and highly variable clinical features. Because of this heterogeneity, predicting disease status remains challenging using any single marker alone. In this study, we explore two complementary data sources: (1) genotypes at 30 candidate SNPs in a South Indian case-control cohort (n = 425) and (2) bulk…
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